Photosensitisation in livestock

Photosensitisation is inflammation of the skin, and occasionally the conjunctiva and cornea of the eye.

Primary photosensitisation can arise as a result of eating a range of plants that contain photosensitising substances. Secondary photosensitisation occurs as a result of liver damage.

Prompt treatment by removing stock from the source of the toxin, keeping them out of direct sunlight and providing nursing care will normally result in recovery.

Early reporting of diseases supports market access

Producers play a vital role in the early detection of exotic diseases in Australia. Reporting diseases early means they can be controlled and eradicated more easily. If you see unusual disease signs, abnormal behaviour or unexpected deaths in your stock, ring your local veterinarian, DAFWA veterinary officer or the Emergency Animal Disease hotline on 1800 675 888.

Call a vet when sheep show signs of photosensitisation to rule out exotic diseases

Photosensitisation of sheep can resemble the exotic diseases foot-and-mouth disease, bluetongue and sheep pox.

 

The Department of Agriculture and Food, Western Australia (DAFWA) provides subsidised veterinary investigations for any livestock disease with high stock losses or similar disease signs to an exotic or reportable disease in order to increase the likelihood of early detection and to provide trading partners with evidence that we are free of particular diseases. For more information about disease investigation subsidies, see the webpage: Subsidised Disease Investigation Pilot Program.

What is photosensitisation?

Photosensitisation is inflammation of the skin, and occasionally conjunctiva and cornea of the eye. Sunlight activates photosensitising substances in these tissues, resulting in local damage. It differs from sunburn in that photosensitisation does not require prolonged exposure to sunlight to develop.

Which animals are most at risk?

All livestock types, breeds and classes can be affected by photosensitisation, but it is less likely to occur in pigmented skin, or skin with a long covering of hair or wool. For this reason, photosensitisation is more likely to be seen in livestock with unpigmented or white skin.

Signs of photosensitisation

The signs of photosensitisation include:

  • severe irritation, restlessness, rubbing and shaking of head and ears
  • seeking shade
  • swelling of affected areas including ears, eyelids, lips and nose. Swelling around the lips and nose may cause difficulty with eating and breathing. Swollen ears droop and may be a distinctive feature
  • discharge from the eyes, conjunctivitis, corneal opacity
  • sometimes lameness (photosensitisation affecting the coronary band)
  • dead and sloughing skin in the affected areas, with underlying tissues becoming inflamed and scabs forming over the inflammation. This is often first noticed at the tips of the ears, but can extend to the whole face, unpigmented areas of the body, and areas of bare skin like the udder, teats, vulva and upper surface of the tail. The tip and underside of the tongue may be affected, as these can be exposed to sunlight when the animal licks its affected lips and muzzle
  • jaundice (yellowing of skin, gums and whites of the eyes) may be noticed in cases of secondary photosensitisation.

Secondary photosensitisation sometimes occurs in livestock grazing:

  • lupins colonised with Diaporthe toxica (Phomopsis sp.), leading to lupinosis
  • Paterson’s curse (Echium plantagineum)
  • Heliotrope (Heliotropium europaeum)
  • Ragwort (Senecio jacobaea) (very restricted distribution in WA).

It may also occur when stock are poisoned by toxic blue-green algae.

Photosensitisation also occasionally occurs spontaneously on some pastures and crops, including biserrula, medics, clovers, oats, barley, wheat, lucerne, canola, and even capeweed. The photosensitising substances or the toxins involved in these occurrences are not known, and in most there is no clear evidence as to whether they are primary or secondary photosensitisation. However, with biserrula there is strong evidence that the photosensitisation is primary.

What causes photosensitisation?

When photosensitising substances accumulate in the bloodstream, they may be exposed to sunlight when passing through capillaries close to the surface of the skin, conjunctiva, cornea and other visible mucous membranes. They are activated by the sunlight and cause local tissue damage and inflammation. Accumulation of photosensitising substances can be a primary or secondary process.

Primary photosensitisation

Primary photosensitisation results from eating (or absorbing through the skin) a photosensitising substance that is not modified in the body. It is associated with livestock grazing:

  • St John’s wort (Hypericum perforatum; contains the photosensitising substance hypericin)
  • Queen Anne’s lace (Ammi majus; contains furanocoumarins)
  • buckwheat (Fagopyrum esculentum; contains fagopyrin)
  • parsley (Petroselinum crispum; contains furanocoumarins).

These plants all have a restricted distribution in Western Australia. To check if these plants are present in your area, go to the Department of Parks and Wildlife website.

Secondary photosensitisation

Secondary photosensitisation is the most common form of this disease in Australia. It occurs following liver damage from consuming plant toxins. In all cases the photosensitising compound is phylloerythrin, produced in the breakdown of chlorophyll in the gastrointestinal tract. Normally, phylloerythrin is absorbed into the blood, then removed by the liver and excreted in the bile. When there is liver damage, this process is disrupted, leading to accumulation of phylloerythrin in the blood and subsequent photosensitisation.

Secondary photosensitisation is most commonly associated with livestock grazing:

  • caltrop (Tribulus terrestris)
  • Brachiaria spp., including signal grass
  • Panicum spp., including some millets
  • ryegrass pastures heavily contaminated with the spores of Pithomyces chartarum, leading to facial eczema
  • rough dog’s tail (Cynosurus echinatus), leading to acute bovine liver disease
  • lantana (Lantana camara) (only a garden plant in WA).
Page last updated: Monday, 21 November 2016 - 2:21pm